NISIN introduction

作者:admin   付款方式:2019-06-22 02:57:32



Nisin is a food preservative which is well-known around the world. 

Vegetal Nisin, two natural types of Vegetal NisinA and Vegetal NisinZ, from Handary is made by fermenting the sauerkraut bacteria of Lactococcus lactis R5 andLactococcus lactis 22186. They have a similar structure but differ in a single amino acid residue at position 27;histidine in Vegetal Nisin A and asparagine in Vegetal Nisin Z.

Both types of Vegetal Nisins are effective against Gram-positive bacteria and has also been shown to be effective against Gram-negative bacteria when applied as part of the hurdle technology approach (simultaneous application of several processes or barriers) to food safety and preservation. Since Nisin (also known as Str. lactic peptide) is a polypeptide, it is rapidly inactivated in the intestine by digestive enzymes after consumption, Extensive micro-biological tests have not shown any cross resistant between Nisin and medical antibacterial drug. Nisin possesses anti-microbial activity against a wide range of Gram-positive bacteria and their spores which causes food spoilage, and especially inhibits the heat-resistant bacilli, such as B. Stearothermophilus, CI. Butyricum and L. Monocytogenes. It is a natural food preservative which is highly efficient, safe and has no side-effects. In addition, it has excellent solubility and stability in food. It is not effective against Gram-negative bacteria, yeasts or mould.


In food applications, Nisin Z has a higher solubility and diffusion characteristics compared with Nisin A in high-acid food, while Nisin A have a higher solubility and diffusion than Nisin Z in weak-acid food, which are important characteristics for food applications. 

Nisin can be used in a wide range of heat-processed foods. These include: fresh milk, processed cheese and other dairy products, pasteurised liquid egg, processed meat, seafood, canned food, fruit drinks, plant protein drinks, baked products, instant food, beer, wine ect. It can also be used as a preservative in gelatin processing, cosmetics, drugs and health products.

General dosage

0.03-0.2gram per kilogram food to be processed Nisin dissolve well in low pHcondition. You may confect solution with PH3-4 and containing 5%Nisin preparation by adding diluted acetic acid, diluted citric acid or 0.02ml/l HCL first, then put it into the food and mix fully. Or, dilutegradually and add. Sometimes, Nisin can be dissolved directly in the original soup of the food. Nisin can also be used together with other food preservatives.

Key benefits

Anti-Gram-positive bacteria

Promote health by preventing head and neck cancer 

Shelf life extension

No impact on flavor

Natural, friendly labelling

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